Carbopol polymers are all high molecular weight, crosslinked polyacrylic acid polymers. However, the polymers differ by crosslink density and can be grouped into the following categories.
Carbopol® homopolymers: acrylic acid crosslinked with allyl sucrose or allyl pentaerythritol
Carbopol® copolymers: acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol
Product Overview and Recommendations
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[table id=8 /] * For above products, pls link every grade with Lubrizol website.
Noveon® AA-1 Polycarbophil Suitable applications of Noveon AA-1 Polycarbophil: Oral and topical Residual solvent for Noveon AA-1 Polycarbophil: Ethyl acetate
Noveon® AA-1 Polycarbophil, USP is a high molecular weight acrylic acid polymer crosslinked with divinyl glycol. It provides excellent bioadhesive properties and has been used extensively to enhance the delivery of active ingredients to various mucous membranes. Noveon AA-1 Polycarbophil can be used for the formulation of buccal, nasal, ophthalmic, vaginal, and rectal bioadhesive products.
Noveon AA-1 Polycarbophil can also be used as a controlled release polymer in oral solid dose applications. Typical usage levels for achieving controlled release characteristics in tablets manufactured by aqueous granulation are 5 – 10 wt.%, depending on the drug properties, co-excipients and processing parameters. http://www.lubrizol.com/LifeScience/Products/NoveonAA-1Polycarbophil.html
Pemulen™ Polymeric Emulsifiers
Pemulen™ polymeric emulsifiers are high molecular weight, copolymers of acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol. They are offered as fluffy, white powders and are primarily used to form stable oil-in-water emulsions. Pemulen polymers contain both hydrophilic and hydrophobic portions within the molecule. The hydrophobic portion of the polymer adsorbs at the oil-water interface, and the hydrophilic portion swells in the water forming a gel network around the oil droplets to provide exceptional emulsion stability.
Pemulen polymers form stable oil-in-water emulsions without the need for any additional surfactants. Therefore, they are ideal for developing low irritancy lotions and creams with elegant skin feel. Pemulen polymers provide viscosity building and high yield value to allow for suspension and stabilization of insoluble materials and particulates.
[table id=9 /] 1Colsolvent system made using cyclohexane and ethyl acetate Typical Product Properties
[table id=10 /] 1 With no secondary emulsifiers
2 Higher oil levels typically require lower pH
3 Higher levels may be needed in formulations with high electrolyte content.