SHINETSU CHEMICAL CO., JAPAN

LOW SUBTITUTED HYDROXYPROPYL CELLULOSE (L-HPC )

Grade

Hydroxy-propoxy content(%)

Particle
Characteristics

Regulatory Status

Application

LH series

LH-11

11

Most fibrous, highly anti-capping effect

USP/EP/JP; DMF, CDMF available

·    Anti-capping agent for Direct compression/ Wet granulation

LH-21

11

Moderately fibrous, regular grade

USP/EP/JP; DMF, CDMF available

·    Binder-disintegrant for Direct compression, Wet granulation

LH-22

8

Moderately fibrous with high swelling speed

USP/EP/JP; DMF, CDMF available

LH-B1

11

Non fibrous/High density with higher swelling force

USP/EP/JP; DMF, CDMF available

·    Fluid-bed granulation, direct compression for high-load formulation

LH-31

11

Micronized, having high binding strength

USP/EP/JP; DMF, CDMF available

·    Pellet extrusion, layering

LH-32

8

Micronized, having high binding strength

USP/EP/JP; DMF, CDMF available

·    Pellet extrusion, layering

NBD series

NBD-020

14

Uniform short fibres  with high binding strength

USP/EP/JP; DMF, CDMF available

·    Wet granulation

NBD-021

11

Uniform short fibres; Regular grade

USP/EP/JP; DMF, CDMF available

·    Direct compression

·    Wet granulation

NBD-022

8

Uniform short fibres with high swelling speed

USP/EP/JP; DMF, CDMF available

·    Oral disintegrating tablet

·    Direct compression

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