LUBRIZOL LIFE SCIENCE POLYMER, USA

Carbopol

Carbopol polymers are all high molecular weight, crosslinked polyacrylic acid polymers. However, the polymers differ by crosslink density and can be grouped into the following categories.

  • Carbopol® homopolymers: acrylic acid crosslinked with allyl sucrose or allyl pentaerythritol
  • Carbopol® copolymers: acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol

Product Overview and Recommendations

   Polymerization SolventProduct Type  
Carbopol®PolymerBenzeneEthyl AcetateCosolvent1HomopolymerCopolymerViscosity, cP
(0.5 wt% at pH 7.5)
71G NF

4,000 - 11,000
971P NF

30,500 - 39,400
974P NF

29,400 - 39,400
980 NF



40,000 - 60,000
981 NF


4,000 - 10,000
5984 EP

4,000 - 11,000
ETD 2020 NF
29,400 - 39,400
Ultrez 10 NF
40,000 - 60,000
934 NF


4,000 - 10,000
934P NF



9,500 - 26,5002
940 NF

30,500 - 39,400
941 NF


47,000 - 77,0002
1342 NF

45,000 - 65,000

Cosolvent system made using cyclohexane and ethyl acetate 1.0 wt%

  • Carbopol homopolyers are polymers of acrylic acid crosslinked with allyl sucrose or allyl pentaerythritol

  • Carbopol copolymers are polymers of acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol

  • Carbopol interpolymers are a carbomer homopolymer or copolymer that contains a block copolymer of polyethylene glycol and a long chain alkyl acid ester


* For above products, pls link every grade with Lubrizol website.

 

Noveon® AA-1 Polycarbophil
Suitable applications of Noveon AA-1 Polycarbophil: Oral and topical
Residual solvent for Noveon AA-1 Polycarbophil: Ethyl acetate

Noveon® AA-1 Polycarbophil, USP is a high molecular weight acrylic acid polymer crosslinked with divinyl glycol. It provides excellent bioadhesive properties and has been used extensively to enhance the delivery of active ingredients to various mucous membranes. Noveon AA-1 Polycarbophil can be used for the formulation of buccal, nasal, ophthalmic, vaginal, and rectal bioadhesive products.
Noveon AA-1 Polycarbophil can also be used as a controlled release polymer in oral solid dose applications. Typical usage levels for achieving controlled release characteristics in tablets manufactured by aqueous granulation are 5 – 10 wt.%, depending on the drug properties, co-excipients and processing parameters.
http://www.lubrizol.com/LifeScience/Products/NoveonAA-1Polycarbophil.html

Pemulen™ Polymeric Emulsifiers

Pemulen™ polymeric emulsifiers are high molecular weight, copolymers of acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol. They are offered as fluffy, white powders and are primarily used to form stable oil-in-water emulsions. Pemulen polymers contain both hydrophilic and hydrophobic portions within the molecule. The hydrophobic portion of the polymer adsorbs at the oil-water interface, and the hydrophilic portion swells in the water forming a gel network around the oil droplets to provide exceptional emulsion stability.

Product Advantages

Pemulen polymers form stable oil-in-water emulsions without the need for any additional surfactants. Therefore, they are ideal for developing low irritancy lotions and creams with elegant skin feel. Pemulen polymers provide viscosity building and high yield value to allow for suspension and stabilization of insoluble materials and particulates.

Product Overview

Pemulen Polymer
Solvent System
Product Type
Viscosity, cP
(1.0 wt% at pH 7.5)1
Suggested Uses
TR-1 NFCosolvent1Copolymer10,000 - 26,500Low irritancy emulsions (lotions and creams) and high clarity gels
TR-2 NFCosolvent1Copolymer4,500 - 13,500Low irritancy emulsions (lotions and creams), high clarity gels and ionic systems

1Colsolvent system made using cyclohexane and ethyl acetate
Typical Product Properties
Typical PropertiesPemulen™ TR-1 NF PolymerPemulen™ TR-2 NF Polymer
Emulsion StabilizationYesYes
Oil Loading1Up to 30%Up to 65 - 80%
Relative ViscosityMediumLow
Yield ValueHighHigh
Effective pH Range24 - 94 - 9
Typical Use Concentration30.15 - 0.3%0.15 - 0.3%

1 With no secondary emulsifiers
2 Higher oil levels typically require lower pH
3 Higher levels may be needed in formulations with high electrolyte content.