ASAHI KASEI

Founded in 1922, the Asahi Kasei Group is a diversified manufacturer centered on chemistry. Throughout more than nine decades of growth, we have continued to proactively diversify and adapt our operating portfolio to changes in the economy, changes in society, and changes in the environment. We are now a major global enterprise with operations in the four business sectors of Chemicals & Fibers, Housing & Construction Materials, Electronics, and Health Care.

Ceolus

Ceolus PH grades are the most commonly used grades for oral solid dosage forms. They show excellent performance when used in granulation and direct compression of tablets.

PH-101Standard grade. Most widely used for wet granulation tableting.
PH-102Larger particle size. Improved flow while maintaining compactibility and distintegration properties similar to PH-101. Used mostly for direct compression tableting.
PH-200Larger particle size than PH-102. Increased flow.
PH-301Higher bulk density than PH-101. Improved flow and disintegration.
PH-302Larger particle size than PH-301 with similar compactibility and disintegration properties to PH-301. Increased flow.

 

CEOLUSTM KG grades

The key to the compactibility of the Ceolus KG grades lies in their needle-like particle shape. Needle-like particles, once compressed, have less elastic recovery and moreparticle-to-particle entanglements to provide greater tablet hardness.
In particular, KG-1000, offers practically required tablet hardness and friability at concentrations of 10% or less.

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KG-grade
 

CEOLUSTM UF grades

The porous structures and more spherical morphology of Ceolus UF grades contribute to their effective plastic deformation and better flow. They are highly compactible and flowable.

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Application of direct compression
Formulation: Ascorbic acid (milled)/MCC/spray-dried lactose/Kiccolate ND-2HS/Mg-St=75/20/3/2/1.5 (weight part)
Tableting: Rotary press (12 punches, 54 rpm with gravity feeder)
Tablet: 180mg, ?8mm, 12R

tablet-img
 

Kiccolate
Croscarmellose Sodium, USP, Ph.Eur, JP

  • Kiccolate is water insoluble disintegrant obtained by cross-linking of carmellose sodium. Asahi Kasei Chemicals distributes 2 grades of Kiccolate, ND-2HS and ND-200 as sole distributor of Nichirin Chemical Industries, Ltd.
  • ND-2HS is suitable for low water solubility drug and ND-200 is suitable for high water solubility drug

 

Kiccolate
Typical properties

 GradeND-2HSND-200
purified water2315
Settling volume (ml)simulated gastric fluid(pH1.2)1713
Simulated intestinal fluid (pH 6.8)2213

Particle size

75?m?200 Mesh?: Not more than 5.0%

Loose bulk density(g/cm3)

0.440.45

Tapped bulk density(g/cm3)

0.650.69

Water holding capacity (times)

7.14.7

Repose angle (°)

4444


??All values are presented only for the purpose of basic reference and not as specifications.
?Settling volume?volume of 1.5g sample after being immersed in test medium for 4hours
?Loose bulk density? Fill sample into vessel and measure without consolidation
?Tapped density ?Pour sample to vessel and measure after mechanically tapping 100 times
?Water holding capacity ?Volume of purified water applied drop wise to 1g sample at the point when powder cannot retain inside and water seep out from surface

 

Special properties and function of Kiccolate

  • Rapid disintegration and dissolution
  • Effective at low use level
  • Less susceptive to pH and viscosity
  • Less susceptive to hardness and compression force
  • Superior stability